Recently, the Indo-Pacific Economic Framework for Prosperity created opportunities for economic integration that enhanced the country's economic stability. This aspect requires the attention of recent studies and policymakers. Hence, the present article examines the impact of opportunities from the Indo-Pacific Economic Framework for Prosperity, such as infrastructural development, energy security, and digital economy, on regional economic integration in Vietnam. The current study also checks the moderating role of international relations among infrastructural development, energy security, digital economy, and regional economic integration in Vietnam. The researchers collected the primary data from the selected respondents using survey questionnaires. The researchers also check the data reliability and association among variables using Smart-PLS. The outcomes indicated that infrastructural development and energy security positively associate with regional economic integration in the context of Vietnam’s joining the Indo-Pacific Economic Framework for Prosperity. The results also revealed that international relations significantly moderate among infrastructural development, energy security, digital economy, and regional economic integration in the context of Vietnam’s joining the Indo-Pacific Economic Framework for Prosperity. The study guides the policymakers in making the policies related to attaining economic integration by properly utilizing Indo-Pacific Economic Framework for Prosperity created opportunities such as infrastructural development, energy security, and digital economy.