Now a day, trade integration is playing an important role in international relations. To foster the cross-border economic activities, the role of trade integration is substantial. Therefore, objective of this study is to examine the role of trade integration and cross-border entrepreneurship in international relations. Thus, the relationship between trade integration, bilateral trade, financial integration, cross-border entrepreneurship, IT infrastructure and international relations was examined. This relationship is examined in comparison between Malaysia and Jordan. To achieve the objective, this study used quantitative research approach along with the cross-sectional research design. Primary data were collected by using a questionnaire from Malaysia and Jordan. Respondents of the study was the employees working among business organizations dealing through cross-border business activities. Results of the study shows no difference between Malaysia and Jordan. It is found that; trade integration has important role to promote international relations. Along with the trade integration, cross-border entrepreneurship activities and IT infrastructure also play an important role to enhance international relations. Therefore, the current study has valuable contribution to the literature and practice by examining the relationship between trade integration, cross-border entrepreneurship, IT infrastructure and international relations.